Modified polymerases and attenuated viruses and methods of use thereof
US7758868B2 · kind B2 · utility
1Cited by
1References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Dec 24, 2007 |
| Grant date | Jul 20, 2010 |
| Priority date | — |
| Expiry date | Dec 24, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses compositions and methods relating to viral polymerases having one or more substitutions of different amino acids at conserved regions of the polymerase yields enzymes with varying rates and fidelity of replication. A universally applicable, polymerase-mechanism-based strategy for production of attenuated viruses and anti-viral vaccines is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.