Targeting complement factor H for treatment of diseases
US7759304B2 · kind B2 · utility
19Cited by
17References
20Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 21, 2007 |
| Grant date | Jul 20, 2010 |
| Priority date | — |
| Expiry date | Jun 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.