Pyrimidine carboxamides

US7759350B2 · kind B2 · utility

Assignee

• Orchid Research Laboratories Limited · IN

Inventors

• Ravikumar Tadipartiii · Viralimalai, IN
• Venkatesan Parameswaran · Chennai, IN
• Rajib Barik · Viralimalai, IN
• Gaddam Om Reddy · Hyderabad, IN
• Pawan Aggarwal · Chennai, IN
• Sappanimuthu Thirunavukkarasu · Chennai, IN
• Sriram Rajagopal · Darsi, IN

Key dates

• Filing date: Sep 7, 2006
• Grant date: Jul 20, 2010
• Expiry date: Mar 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly relates to novel pyrimidine carboxamides of the general formula (I). Also included is a method of prophylaxis or treatment of a pain disorder, immunological diseases, inflammation, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal compris…