Piperidine-substituted indoles

US7759365B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Domnic Martyres · Biberach, DE
• Pascale Pouzet · Biberach, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Peter Seither · Biberach an der Riß, DE
• Silke Hobbie · Biberach, DE
• Thierry Bouyssou · Mietingen, DE

Key dates

• Filing date: Apr 26, 2006
• Grant date: Jul 20, 2010
• Expiry date: Jan 8, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula 1:wherein R1, R5, R6, R7, A, B, D-E, Y, i, j, n and m are defined as below.The compounds of formula 1 are useful as agonists or antagonists of CCR-3. The present invention is also directed to pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.