Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

US7759379B2 · kind B2 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Hartmut Strobel · Liederbach, DE
• Sven Ruf · Mainz, DE
• Dominique Lesuisse · Montreuil, FR
• Conception Nemecek · Thiais, FR
• Youssef El-Ahmad · Créteil, FR
• Stefan Guessregen · Frankfurt am Main, DE
• Anne Lebrun · Paris, FR
• Kurt Ritter · Heidelberg, DE
• Didier Benard · Villiers-le-Bel, FR
• Augustin Hittinger · Igny, FR
• Herve Bouchard · Thiais, FR

Key dates

• Filing date: Jan 26, 2007
• Grant date: Jul 20, 2010
• Expiry date: Jul 29, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula (I):in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.