Small molecule inhibitors of MDM2 and the uses thereof

US7759383B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Ke Ding · 流花街道, CN
• Yipin Lu · Emeryville, US
• Zaneta Nikolovska-Coleska · Ann Arbor, US
• Su Qiu · Ann Arbor, US
• Guoping Wang · Naperville, US
• Dongguang Qin · Auburn Hills, US
• Sanjeev Kumar · Ann Arbor, US

Key dates

• Filing date: Feb 22, 2006
• Grant date: Jul 20, 2010
• Expiry date: Aug 27, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).