Phenylalanine derivatives

US7759388B2 · kind B2 · utility

Assignee

• Ajinomoto Co., Inc.

Inventors

• Nobuyasu Suzuki · Kawasaki, JP
• Toshihiko Yoshimura · Kawasaki, JP
• Hiroyuki Izawa · Kawasaki, JP
• Kazuyuki Sagi · Kawasaki, JP
• Shingo Makino · Kawasaki, JP
• Eiji Nakanishi · Kawasaki, JP
• Masahiro Murata · Kawasaki, JP
• Takashi Tsuji · Kyoto, JP

Key dates

• Filing date: Oct 16, 2008
• Grant date: Jul 20, 2010
• Expiry date: Oct 16, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.