Patent · US Expired

N-glycosylated antibody

US7759464B2 · kind B2 · utility

0Cited by

0References

12Claims

0Family size

Assignees

GREENOVATION BIOTECH GMBH · DE
MERIDIAN BIOPHARMACEUTICALS GMBH · AT

Inventors

Manfred Schuster · Schrick, AT
Gottfried Himmler · Groß-Enzersdorf, AT
Gunter Waxenecker · Mank, AT
Geert Mudde · Purkersdorf, AT
Manuela Loidl · Stockerau, AT
Gerda Redl · Groß-Enzersdorf, AT
Hans Loibner · Wien, AT

Key dates

Filing date	Jul 14, 2004
Grant date	Jul 20, 2010
Priority date	—
Expiry date	Nov 29, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/734
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.