Humanized collagen antibodies and related methods

US7763247B2 · kind B2 · utility

Assignee

• Cell Matrix, Inc. · US

Inventors

• Jeffry D. Watkins · Encinitas, US
• William D. Huse · Del Mar, US
• Ying Tang · San Diego, US
• Daniel Broek · Los Angeles, US
• Peter Brooks · Carmel, US

Key dates

• Filing date: Feb 15, 2008
• Grant date: Jul 27, 2010
• Expiry date: Jun 1, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.