Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection
US7763259B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 6, 2004 |
| Grant date | Jul 27, 2010 |
| Priority date | — |
| Expiry date | Feb 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/20034
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compositions including a chimera of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. The present invention also provides complexes comprising chimeras of papillomavirus L2 polypeptides non-covalently associated with papillomavirus L1 polypeptides, and GST fusions thereof. These compositions may be used to elicit immune responses in a patient to papillomavirus. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infection, especially papillomavirus infection and cervical cancers and warts associated therewith, made from compositions of this invention, are also disclosed. Nucleic acids and expression vectors coding for compositions of this invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.