Patent · US Active

Process for preparation of highly pure isotretinoin

US7763748B2 · kind B2 · utility

0Cited by

2References

19Claims

0Family size

Assignee

IPCA LABORATORIES LIMITED · IN

Inventors

Ashok Kumar · Jamkhed, IN
Dharmendra Singh · Mumbai, IN
Ganesh Devidas Mahale · Jamkhed, IN
Ragnesh Kumar Rana · Jamkhed, IN
Mahesh Kharade · Jamkhed, IN

Key dates

Filing date	Feb 20, 2008
Grant date	Jul 27, 2010
Priority date	—
Expiry date	Feb 20, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C403/20
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for preparation of isotretinoin and more specifically, to a purification process for obtaining highly pure isotretinoin that is useful as a keratolytic agent, particularly useful for the treatment of acne. The process involves treating isotretinoin containing metal contamination and/or other impurities with a base in a suitable solvent to form a solution of isotretinoin, followed by adsorption, precipiation, and filtration or centrifugation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.