Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device

US7764996B2 · kind B2 · utility

Assignee

• Cardiac Pacemakers, Inc. · US

Inventors

• Yi Zhang · Mountain View, US
• John D. Hatlestad · Burnsville, US
• Gerrard M. Carlson · Champlin, US
• Yousufali Dalal · St. Louis Park, US
• Marina Brockway · Shoreview, US
• Kent Lee · Shoreview, US
• Richard O. Kuenzler · Shaker Heights, US
• Carlos Haro · Windom, US
• Krzysztof Z. Siejko · Maple Grove, US
• Abhilash Patangay · Inver Grove Heights, US

Key dates

• Filing date: Oct 31, 2006
• Grant date: Jul 27, 2010
• Expiry date: Mar 9, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H50/30
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.