Formulation and use thereof

US7767698B2 · kind B2 · utility

Assignee

• McNeil AB · US

Inventors

• Mark P. Warchol · Kalamazoo, US
• Folke Moren · Malmö, SE
• Kristina Thyresson · Lund, SE
• Elisabeth Sthengel · Helsingborg, SE
• Sven-Borje Andersson

Key dates

• Filing date: Jun 2, 2003
• Grant date: Aug 3, 2010
• Expiry date: Jun 23, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A liquid pharmaceutical formulation comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a short period of time after administration.The administration is preferably by spraying an aerosol into the oral cavity for further distribution essentially into the lungs. A method for manufacturing said formulation. Use of said formulation in therapy, such as therapy for treating addiction to tobacco.