Patent · US Active

Process for preparing renin inhibitors

US7767831B2 · kind B2 · utility

0Cited by

7References

2Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Stuart J. Mickel · Lausen, CH
Gottfried Sedelmeier · Schallstadt, DE
Hans Hirt · Reinach, CH
Frank Schäfer · Weilheim, DE
Michael Foulkes · Redwood City, US
Walter Prikoszovich · Amriswil, CH

Key dates

Filing date	Jun 6, 2006
Grant date	Aug 3, 2010
Priority date	—
Expiry date	Nov 17, 2026

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III,wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I,with a reagent able to transform hydroxy into X where X is for example a leaving group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.