System, device and method for detection of several individual analytes in a solution, and a disposable flow cell for use therein

US7771657B2 · kind B2 · utility

Assignee

• Biosensor Applications Sweden AB · SE

Inventors

• Per Mansson · Sollentuna, SE
• Henrik Andersson · Reftele, SE
• Jan Smith · Stuvsta-Snättringe, SE
• Kjeld Jensen · London, GB
• Teodor Aastrup · Stockholm, SE

Key dates

• Filing date: Jun 18, 2003
• Grant date: Aug 10, 2010
• Expiry date: Jun 18, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2291/106
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing a piezoelectric crystal (50) carrying electrodes (56,62) and a coating (66,46) exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means (70) flows a solution (75) and the test solution aliquot (83) to and through a cell compartment of each of the cells (10) via the connecting station (100). Power and measurement means (130) oscillate the piezoelectric crystal(s) (50). A change in oscillating characteristics of the crystal(s) (50), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s). Further, disposable flow cells (10) for use in an array of individually operated piezoelectric crystal microbalances (112) is described.