Method for identification of Tr1 lymphocytes regulators by the presence and over-expression of specific molecules and application thereof
US7771932B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 2004 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Dec 18, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/686
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method for identification of Tr1 lymphocyte regulators in a biological sample, based on the determination of the simultaneous presence of the molecular group CD4, CD18 and/or CD11a, CD49b and, where appropriate, by the demonstration of an over-expression of genes coding for the molecules CD4, PSGL-1, PECAM-1 and alphaV/beta3. The invention further relates to a method of quantification and a prognostic or diagnostic method for auto-immune or inflammatory diseases, based on said identification method. The invention also relates to an enrichment method for Tr1 lymphocyte regulators, based on the determination of the simultaneous presence of said molecules and, finally, an enriched composition from said enrichment method, for the treatment of an auto-immune or inflammatory disease, in particular Crohn's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.