Methods for determining genetic haplotypes and DNA mapping

US7771944B2 · kind B2 · utility

Assignees

• The Board of Trustees of the University of Illinois · US
• The Regents of the University of California · US

Inventors

• Ming Xiao · Huntingdon Valley, US
• Pui-Yan Kwok · Clayton, US
• Paul R. Selvin · Berkeley, US
• Mathew Gordon · Palo Alto, US

Key dates

• Filing date: Dec 14, 2007
• Grant date: Aug 10, 2010
• Expiry date: Dec 14, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6874
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Improved methods of genetic haplotyping and DNA sequencing and mapping, including methods for making amplified ssDNA, methods for allele determination, and a DNA barcoding strategy based on direct imaging of individual DNA molecules and localization of multiple sequence motifs or polymorphic sites on a single DNA molecule.