Micromachined diagnostic device with controlled flow of fluid and reaction
US7771989B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 24, 2009 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Aug 24, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54389
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer chamber, a capture zone and a waste chamber. Each of these device components are interconnected through microfluidic channels. This invention further relates to the method of operating a micromachined microfluidic diagnostic device. The flow of fluid in the microchannels is regulated through micromachined valves. The reaction of sample analytes with fluorescent tags and detection antibodies in the reaction chamber are enhanced by the micromachined active mixer. By ejecting reaction mixture onto the capture zone through micromachined fluid ejector array, the fluorescent tagged analytes bind with capturing antiodies on capture zone. The fluid ejector array further ejects buffer fluid to wash away unbound fluorescent tags.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.