Substances directed against a specific sequence essential for heparanase catalytic activity and uses thereof as heparanase inhibitors
US7772187B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 28, 2004 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Sep 12, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amino acid sequence derived from the N′ terminus region of the 50 Kd subunit of heparanase, preferably, the sequence including amino acid residues Lys158-Asn171 of human heparanase and any functional fragments thereof. Compositions for the inhibition of heparanase glycosidase catalytic activity, having as an active ingredient an isolated and purified peptide as the amino acid sequence. An antibody directed to the sequence and compositions and uses thereof as heparanase inhibitor. The use of the amino acid sequence in a screening method for specific heparanase inhibitors. Compositions including the heparanase inhibitors and methods for the treatment of heparanase related disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.