Methods and compositions for controlling efficacy of RNA silencing
US7772203B2 · kind B2 · utility
98Cited by
1References
64Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2008 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Jul 14, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A40/146
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.