2′,3′-dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections

US7772208B2 · kind B2 · utility

Assignees

• Pharmasset, Inc. · US
• The Board of Trustees of the Leland Stanford Junior University · US
• EMORY UNIVERSITY · US

Inventors

• Raymond F. Schinazi · Decatur, US
• Robert Striker · Madison, US
• Junxing Shi · Duluth, US

Key dates

• Filing date: Jan 8, 2008
• Grant date: Aug 10, 2010
• Expiry date: Jan 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a β-L- or β-D-2′,3′-dideoxynucleoside or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable diluent or excipient.