Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
US7772218B2 · kind B2 · utility
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Key dates
| Filing date | Aug 9, 2004 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Dec 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J5/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.