N-sulphonylated amino acid derivatives, method for the production and use thereof

US7772251B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Jörg Stürzebecher · Erfurt, DE
• Torsten Steinmetzer · Jena, DE
• Andrea Schweinitz · Jena, DE
• Anne Stürzebecher · Weimar, DE
• Kerstin Uhland · Planegg, DE

Key dates

• Filing date: May 17, 2004
• Grant date: Aug 10, 2010
• Expiry date: Feb 17, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/79
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to N-sulfonylated amino acid derivatives, where an aryl radical is linked via the sulfonyl group N-terminally to the amino acid and a radical which comprises at least one imino group and at least one further basic group which represents an optionally modified amino, amidino or guanidino group is linked C-terminally via the carbonyl group. The invention likewise relates to processes for preparing these compounds and to their use, in particular as inhibitors of matriptase.