Optical resolution method of amlodipine
US7772400B2 · kind B2 · utility
13Cited by
4References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 2, 2005 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Sep 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.