Patent · US Active

3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors

US7772405B2 · kind B2 · utility

4Cited by

7References

16Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Gottfried Sedelmeier · Schallstadt, DE
Dominique Grimler · Basel, CH
Murat Acemoglu · Basel, CH

Key dates

Filing date	Oct 16, 2006
Grant date	Aug 10, 2010
Priority date	—
Expiry date	Apr 29, 2027

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II,or a salt thereof, and a compound of formula VIor a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these.Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.