Amino or thiol linker building block for the synthesis of amino- or thiol-functionalized nucleic acids and methods of making and use thereof
US7772439B2 · kind B2 · utility
1Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Oct 25, 2005 |
| Grant date | Aug 10, 2010 |
| Priority date | — |
| Expiry date | Jan 22, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/2408
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure:is provided. Such building block may be introduced in the 5′ end position of an amino acid under standard coupling conditions. Such building block allows in-line coupling control, “trityl-on” purification, and solid support functionalization/derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.