Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis
US7776313B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 25, 2007 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | Nov 8, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/105
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.