Methods and compositions for treatment of ion imbalances

US7776319B2 · kind B2 · utility

Assignee

• Relypsa, Inc. · US

Inventors

• Robert Alpern · Woodbridge, US
• Jerry M. Buysse · Los Altos, US
• Han-Ting Chang · Livermore, US
• Dominique Charmot · Campbell, US
• Michael J. Cope · Berkeley, US
• John Fordtran · Dallas, US
• Gerrit Klaerner · Los Gatos, US
• Eric Connor · Los Gatos, US
• Mingjun Liu · Campbell, US
• Futian Liu · Sunnyvale, US
• Jun Shao · Fremont, US

Key dates

• Filing date: Mar 30, 2005
• Grant date: Aug 17, 2010
• Expiry date: May 1, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F128/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.