Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex
US7776320B2 · kind B2 · utility
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Key dates
| Filing date | May 10, 2006 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | Jun 20, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A protocol for use of growth factors to stimulate neuronal cell growth and activity in trkB receptor containing cortical tissues, including the entorhinal and hippocampal cortices. The method introduces exogenous growth factor, such as BDNF, NT-4/5 and NT-3, into the EC. The method is useful in therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as Alzheimer's disease or for normal aging.
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