Coronavirus isolated from humans

US7776521B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · US

Inventors

• Paul A. Rota · Decatur, US
• Larry J. Anderson · Atlanta, US
• William J. Bellini · Lilburn, US
• Michael D. Bowen · Decatur, US
• Cara Carthel Burns · Avondale Estates, US
• Raymond Campagnoli · Decatur, US
• Qi Chen · Marietta, US
• James A. Comer · Decatur, US
• Byron T. Cook · Augusta, US
• Shannon L. Emery · Atlanta, US
• Dean D. Erdman · Decatur, US
• Cynthia Goldsmith · Lilburn, US
• Jeanette Guarner · Decatur, US
• Charles D. Humphrey · Lilburn, US
• Joseph P. Icenogle · Atlanta, US
• Thomas G. Ksiazek · Lilburn, US
• Richard F. Meyer · Roswell, US
• Stephan S. Monroe · Decatur, US
• William Allan Nix · Bethlehem, US
• M. Steven Oberste · Alpharetta, US
• Christopher D. Paddock · Atlanta, US
• Teresa C. T. Peret · Atlanta, US
• Pierre E. Rollin · Lilburn, US
• Mark A. Pallansch · Lilburn, US
• Anthony Sanchez · Lilburn, US
• Wun-Ju Shieh · Norcross, US
• Suxiang Tong · Alpharetta, US
• Sherif R. Zaki · Atlanta, US

Key dates

• Filing date: May 14, 2007
• Grant date: Aug 17, 2010
• Expiry date: Aug 18, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.