Patent · US Active

Psoriasin expression by breast epithelial cells

US7776541B2 · kind B2 · utility

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4Claims

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Assignee

DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

Kornelia Polyak · Baltimore, US
Charlotta Enerback · Gothenburg, SE

Key dates

Filing date	Dec 8, 2008
Grant date	Aug 17, 2010
Priority date	—
Expiry date	Dec 8, 2028

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/57415
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS) These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5 gene expression in breast tissue from a subject suspected of having, or at risk of having, high grade DCIS. The invention also embodies a method of inhibiting expression of HID-5 protein in DCIS cells and methods of treating a subject suspected of having, or at risk of having, high grade DCIS.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.