Dimeric and trimeric nucleic acid dyes, and associated systems and methods
US7776567B2 · kind B2 · utility
142Cited by
32References
18Claims
0Family size
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Key dates
| Filing date | Mar 16, 2006 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | Mar 17, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/686
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.