Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

US7776595B2 · kind B2 · utility

Assignee

• JOHNSON & JOHNSON RESEARCH PTY. LIMITED · AU

Inventors

• Geoffrey Phillip Symonds · Mandurah, AU
• Rafael Amado · Westlake Village, US
• Lun-Quan Sun · Sydney, AU
• Janet Lesley Macpherson · Sydney, AU
• Gregory Fanning · Sydney, AU
• Wayne Gerlach · Acacia Hills, AU

Key dates

• Filing date: Aug 18, 2006
• Grant date: Aug 17, 2010
• Expiry date: Mar 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.