Triazole derivative or salt thereof
US7776897B2 · kind B2 · utility
38Cited by
4References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 14, 2005 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | Apr 10, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a compound which can be used for therapy of diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular diabetes, insulin resistance.It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.