Nitroaniline-based alkylating agents and their use as prodrugs
US7776924B2 · kind B2 · utility
1Cited by
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10Claims
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Key dates
| Filing date | Oct 8, 2003 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | Apr 10, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.