Azaindazole compounds and methods of use

US7777035B2 · kind B2 · utility

Assignee

• CHEMOCENTRYX, INC. · US

Inventors

• Penglie Zhang · Foster City, US
• Andrew Pennell · San Francisco, US
• John J. Wright · Evansville, US
• Wei Chen · Fremont, US
• Manmohan Reddy Leleti · Sunnyvale, US
• Yandong Li · San Jose, US
• Lianfa Li · Palo Alto, US
• Yuan Xu · Singapore, SG
• Mark M. Gleason · Bloomfield, US
• Yibin Zeng · Foster City, US
• Kevin Lloyd Greenman · Sunnyvale, US

Key dates

• Filing date: May 22, 2007
• Grant date: Aug 17, 2010
• Expiry date: Jul 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds.