Method of identifying a chemical entity which is a hydroxylase modulator
US7778779B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Oct 16, 2003 |
| Grant date | Aug 17, 2010 |
| Priority date | — |
| Expiry date | May 6, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.