Diagnosis of gluten sensitive enteropathy and other autoimmunopathies

US7781169B1 · kind B1 · utility

Inventors

• Mats Paulsson · Cologne, DE
• Uwe Odenthal · Cologne, DE
• Neil Smyth · Cologne, DE
• Daniel Aeschlimann · Madison, US
• Sarolta Karpati · Budapest, HU
• Miklos Sardy · Budapest, HU

Key dates

• Filing date: Jun 28, 2000
• Grant date: Aug 24, 2010
• Expiry date: Jul 5, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/811
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue transglutaminase, tissue-specific transglutaminases, or other transglutaminases. It was found that autoimmune diseases other than celiac disease can be diagnosed and distinguished in this way, notably, dermatitis herpetiformis Duhring, Crohn's disease, Addison's disease, AI hemolytic anemia, AI thrombocytopenic purpura, AI thyroid diseases, atrophic gastritis—pernicious anemia, IgA nephropathy or IgA glomerulonephritis, myasthenia gravis, partial lipodystrophy, polymyositis, primary biliary cirrhosis, primary sclerosing cholangitis, recurrent pericarditis, relapsing polychondritis, rheumatoid arthritis, rheumatism, sarcoidosis, Sjögren's syndrome, SLE, splenic atrophy, type I (insulin-dependent) diabetes mellitus, diabetes mellitus of other types, ulcerative colitis, vasculitis (both systemic and cutaneous), vitiligo as well as autoimmune diseases associated with infertility, increased risk of abortion, or reduced fetal growth.