Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7781576B2 · kind B2 · utility
28Cited by
128References
38Claims
0Family size
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Key dates
| Filing date | Dec 22, 2006 |
| Grant date | Aug 24, 2010 |
| Priority date | — |
| Expiry date | Mar 25, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is provided for the preparation of a key intermediate in the preparation of 2′-branched nucleoside compounds. The process includes contacting a protected precursor 3,4-O-isopropylidene-2-C-substituted-D-arabinono-1,5-lactone with a fluorinating agent under anhydrous conditions and converting the precursor into a protected 2-deoxy-2-halo-2-C-disubstituted ribono-1,5-lactone and optionally into a 2-deoxy-2-halo-2-C-disubstituted ribono-1,4-lactone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.