Stilbene derivatives as new cancer therapeutic agents
US7781580B2 · kind B2 · utility
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Key dates
| Filing date | Apr 23, 2007 |
| Grant date | Aug 24, 2010 |
| Priority date | — |
| Expiry date | Mar 17, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Stilbene derivatives exhibit killing and suppression of growth activity against a variety of cancer cells, and are effective at suppressing tumor growth in vivo. The stilbene derivatives may be used in the treatment of diseases characterized by cell hyperproliferation including human malignancies and non-malignant diseases such as liver cirrhosis. Stilbenes may also disrupt abnormal vessels in tumor to achieve vascular disrupting effect to suppress tumor growth. Water soluble pro-drug forms of stilbene derivatives are particularly useful in suppressing tumor growth in vivo.
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