Substituted 3-cyanopyridines as protein kinase inhibitors

US7781591B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Derek Cecil Cole · New City, US
• Diane H. Boschelli · New City, US
• Yanong Wang · Hackettstown, US
• Magda Asselin · Mahwah, US
• Diane Joseph-McCarthy · Belmont, US
• Amarnauth Shastrie Prashad · Garnerville, US
• Allan Wissner · Monsey, US
• Russell Dushin · Old Lyme, US
• Biqi Wu · Nanuet, US
• Lawrence Nathan Tumey · Fairview Park, US
• Chuan S. Niu · Cheshire, US
• Joan Chen · Great Neck, US

Key dates

• Filing date: Jun 13, 2007
• Grant date: Aug 24, 2010
• Expiry date: Mar 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present teachings provide compounds of formula Iand their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.