Patent · US Active

Mammalian-type glycosylation in transgenic plants expressing mammalian β1,4-galactosyltransferase

US7781647B2 · kind B2 · utility

17Cited by

13References

15Claims

0Family size

Assignee

Stichting Dienst Landbouwkundig Onderzoek-PPO/PRI · NL

Inventors

Hendrikus Antonius Cornelis Bakker · Hannover, DE
Hendrik Jan Bosch · Utrecht, NL

Key dates

Filing date	Feb 8, 2007
Grant date	Aug 24, 2010
Priority date	—
Expiry date	Feb 8, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/8258
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides plants and plant cells comprising of functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, for example mammalian β 1,4-galactosyltransferase, said plants or plant cells additionally comprising at least a second mammalian protein or functional fragment thereof, for example a mammalian antibody, that is normally not present in plants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.