Design and synthesis of renal dipeptidase inhibitors

US7785564B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Saeed R. Khan · Owings Mills, US
• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Hallur Gurulingappa · Baltimore, US
• Phillip Buckhaults · Columbia, US

Key dates

• Filing date: Jul 7, 2005
• Grant date: Aug 31, 2010
• Expiry date: Mar 11, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.