Modified tumor necrosis factor
US7785579B2 · kind B2 · utility
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11References
20Claims
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Key dates
| Filing date | Feb 27, 2006 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Jun 5, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/144
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000, significantly increases the circulating half-life of the TNF while not increasing its toxicity. As a result, lower doses of the TNF may be administered to effectively treat tumors with fewer, accompanying adverse side effects to the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.