Acid alpha-glucosidase and fragments thereof
US7785856B2 · kind B2 · utility
47Cited by
49References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2007 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Sep 16, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/2408
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.