Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
US7785898B2 · kind B2 · utility
4Cited by
17References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 30, 2003 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Apr 24, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25375
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell-maternal antibody complexes are identified and isolated using labelled agents that bind to the maternal antibodies. The present invention also provides fetal cells, isolated by use of said maternal antibodies, as a source of fetal DNA for prenatal genetic diagnosis of the fetus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.