Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof

US7786098B2 · kind B2 · utility

Assignee

• Zhejiang Dade Pharmaceutical Group Co., Ltd. · CN

Inventors

• Weiping Shen · Shanghai, CN
• Jianping Wang · Västerås, SE
• Jianguo Wang · Horseheads, US
• Hongmei Jin · 安丰镇, CN
• Feng Qian · Minneapolis, US
• Fei Wang · Beijing, CN

Key dates

• Filing date: Nov 22, 2006
• Grant date: Aug 31, 2010
• Expiry date: May 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.