Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
US7786110B2 · kind B2 · utility
3Cited by
2References
16Claims
0Family size
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Key dates
| Filing date | Nov 8, 2007 |
| Grant date | Aug 31, 2010 |
| Priority date | — |
| Expiry date | Nov 14, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/66
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B,and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.