Heterocyclic compounds as pSTAT3/IL-6 inhibitors

US7786142B2 · kind B2 · utility

Assignee

• Orchid Research Laboratories Limited · IN

Inventors

• Siripragada Mahender Rao · Poonamallee, IN
• Akella Satya Surya Visweswara Srinvas · Chennai, IN
• Shikha Rani · Chennai, IN
• Gaddam Om Reddy · Hyderabad, IN
• Sriram Rajagopal · Darsi, IN
• Uma Ramachandran · Chennai, IN
• Duddu Savaraiah Sharada · Chennai, IN
• Rajagopalan Nirmala · Chennai, IN
• Velaiah Sivasudar · Chennai, IN
• Lakshmanan Manikandan · Chennai, IN
• Ramachandran Balaji · Chennai, IN

Key dates

• Filing date: Oct 12, 2006
• Grant date: Aug 31, 2010
• Expiry date: May 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above