Patent · US Active

Synthesis methods and intermediates for the manufacture of Rizatriptan

US7786156B2 · kind B2 · utility

0Cited by

2References

20Claims

0Family size

Assignee

ratiopharm GmbH · DE

Inventors

Pierre Martin · Rheinfelden, CH
Ulrich Berens · Binzen, DE
Andreas Boudier · Zürich, CH
Oliver Dosenbach · Bad Bellingen, DE

Key dates

Filing date	Jan 27, 2005
Grant date	Aug 31, 2010
Priority date	—
Expiry date	Apr 19, 2027

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A],or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.